Calebin A (Feruloylmethylferulate) is also found naturally in trace amounts in Curcuma species (Curcuma longa / caesia). Calebin A belongs to a family of ferulate esters, rightfully called Calebenoids, which seem more stable than Curcumin in physiological medium. It also shows higher chemical stability in acidic and basic media in contrast with the noted instability of Curcumin at higher pH values while sharing several physiological properties with Curcumin. Calebin A was shown to exhibit a variety of pharmacological activities similar to Curcumin (Oliveira et al., 2015).

Calebin A could be a potential compound in managing various human ailments like metabolic disorders, obesity, arthritis, low bone density, and cancer. Recently, Calebin A was also shown to be involved in the histone modulation (Histone deacetylase and p300/CBP associated factor) activities that are associated with epigenetic mechanisms (Novaes et al., 2017).

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doi: 10.3390/pharmaceutics9040045.