Management of Metabolic Syndrome*

Administration of CurCousin™ resulted significant reduction in
– Hepatic triglycerides
– Lipid accumulation
– Inflammatory infiltration, and
– Ballooning degeneration of the liver

CurCousin™ helps to prevent and treat obesity and non-alcoholic fatty liver disease (Lai et al., 2015).

Continue Reading : doi: 10.1002/mnfr.201400809

Continue Reading : doi: 10.1002/mnfr.201400809

e) Improved Serum Markers

Adipokines like leptin and adiponectin are the hormones produced by white adipose tissues, which play a pivotal role in the energy homeostasis processes. These adipokines also control metabolism and immunity.

CurCousin™ favorably modulates adipokines in high-fat diet fed mice (Figure 2). Notable modulatory properties of CurCousin™ included inhibition of leptin production, increase in adiponectin expression, and inhibition of local (adipocyte) and systemic inflammation caused by pro-inflammatory cytokines, like tumor necrosis factor alpha (TNF-α), interleukin (IL)-6 and IL-1ß (Unpublished observation).


Figure 2:  Concentration of (A) adiponectin (ng/ml) (B) leptin (pg/ml) levels in serum of experimental animals

Other Benefits*

a) Prevention of Bone Damage

CurCousin™ effectively suppresses osteoclastogenesis induced by multiple myeloma and breast cancer cells via the inhibition of the NF-kB signaling pathway, which is mandatory for RANKL-induced osteoclastogenesis (Tyagi et al., 2016). Thus, CurCousin™ can effectively manage secondary bone lesions associated with cancer and nonmalignant diseases such as postmenopausal osteoporosis and rheumatoid arthritis.

Continue Reading : doi: 10.1016/

b) Treatment of Arthritis

CurCousin™ showed potential protecting activity for mammalian articular cartilage from pathological damages in animal models. For inflammation studies, adjuvant arthritis was induced in Albino Wistar rats of either sex by the injection of heat-killed Mycobacterium tuberculosis and analyzed the effect of CurCousin™ in improving paw edema and associated markers. The in vivo studies revealed that CurCousin™ significantly reduced acute inflammation and edema in Carrageenan-induced rats (Table 1) (Unpublished observation).

Table 1: Effect of CurCousin™ on paw edema in adjuvant-induced arthritic rats

Test MaterialsDoses
(mg/kg p.o.)
%Inhibitory Activity
CurCousin™2.519.21 %
537.16 %
1039.40 %
2043.44 %
Acetyl salicylic acid (Standard)10038.5 %

Moreover, CurCousin™ could effectively modulate the cellular immune system by inhibiting the expression of CD4+ and CD8+ cells and associated cytokines and showed significant anti-arthritic activity.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, mitigate or prevent any disease.