Clinical Studies

Clinical Study I : Efficacy and Tolerability of a Novel Formulation for Weight Management in Obese Subjects: A Randomized, Double Blind, Placebo Controlled, Clinical Study
Objective and Study Design

A Randomized, Double-blind, Mono-centric, Placebo controlled study was conducted to assess the efficacy and safety of Calebin A in managing weight in 40 obese or overweight individuals for 90 days.t.

Dosage

Subjects were administered Calebin A capsules (25 mg, one capsule twice a day) or placebo.

Results
  • Significant reduction in body weight and body mass index were observed in the Calebin A group compared with placebo after 90 days
  • Significant change in serum biomarkers like leptin, adiponectin, and cortisol was observed in the study subjects with improved blood lipid profiles (Figure 3)
  • Moreover, Calebin A was found to be safe and well-tolerated by all the subjects
Conclusion

Clinical study showed that Calebin A is effective in managing healthy body weight by inhibiting adipogenesis and is an ideal candidate to support metabolic health.

Continue Reading :doi: https://ijapr.in/index.php/ijapr/article/view/499
Clinical Study II : A minor metabolite from Curcuma longa effective against metabolic syndrome: results from a randomized, double-blind, placebo-controlled clinical study
Objective and Study Design

Multicentric, Randomized, double blinded, placebo controlled clinical trial was conducted to assess the safety and efficacy of supplementation of CurCousin® containing Calebin-A in management of metabolic imbalances, healthy weight and lipid management.

Dosage

Capsule containing 25mg of Calebin A (CurCousin®) and 3mg of Piperine (BioPerine®) was administered twice a day, or placebo.

Results
  • Statistically significant improvement in body weight, waist circumference, BMI as compared to placebo group.
  • Supplementation resulted in positive effect on reducing the circulating levels of leptin hormone.
  • C reactive proteins, showed significant lowering in Calebin A supplementation group.
  • CurCousin® containing Calebin A was found to be safe and well tolerated by all the participants.
Conclusion

Results from the clinical trial showed that CurCousin® at the suggested dosage was safe and efficacious for management of healthy body weight as well as healthy lipid levels and promoting healthy metabolism.

curcousin-clinical-infographic
Figure 3: Health benefits of Calebin A as observed in the clinical study
Continue Reading :doi: https://pubmed.ncbi.nlm.nih.gov/37114318/
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